Sympathetic stimulation and hypertension in the pyridoxine-deficient adult rat.
نویسندگان
چکیده
Pyridoxal phosphate is the coenzyme of various decarboxylases involved in the formation of monoamine neurotransmitters such as gamma-aminobutyric acid, serotonin, dopamine, and norepinephrine. Adult male Sprague-Dawley rats placed on a pyridoxine-deficient diet for 8 weeks showed significant hypertension compared with pyridoxine-supplemented controls. Hypothalamic contents of pyridoxal phosphate, gamma-aminobutyric acid, and serotonin in the pyridoxine-deficient rats were significantly lower than those in pyridoxine-supplemented controls. Hypertension was associated with sympathetic stimulation. Treatment of pyridoxine-deficient rats with a single dose of pyridoxine (10 mg/kg body weight) reversed the blood pressure to normal levels within 24 hours, with concomitant restorations of hypothalamic serotonin and gamma-aminobutyric acid as well as the return of plasma norepinephrine and epinephrine to normal levels. Also, pyridoxine treatment reversed the hypothalamic hypothyroidism observed in pyridoxine-deficient rats. These results indicate an association between pyridoxine deficiency and sympathetic stimulation leading to hypertension.
منابع مشابه
Treatment of Iatrogenic and Age Related Hypertension and Pharmaceutical Compositions Useful Theren Field of the Invention
The Effects of Vitamin B6 on the Systolic Blood Pressure of Rats in Various Animal Models of Hypertension, Lal et al., Journal of Hypertension 1996, vol. 14, No. 3, 355-362. Hypotensive Action of 5-HT Receptor Agonists in the Vitamin B6-Deficient Hypertensive Rat, Lal et al., Euro pean Journal of Pharmacology, 234(1993) 183-189. Sympathetic Stimulation and Hypertension in the Pyridox ine-Defici...
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ورودعنوان ژورنال:
- Hypertension
دوره 11 4 شماره
صفحات -
تاریخ انتشار 1988